Gertrud-Alexandra PALTINEAN1, Gheorghe TOMOAIA2,3, Levente-Zsolt RACZ1, Aurora MOCANU1, Maria TOMOAIA-COTISEL1,3
Abstract. This review examines the interaction between silymarin (SIL) and other plantbased bioactive compounds such as curcumin (CCM), piperine (PIP), resveratrol (RES), and icariin (ICA). Their combination revealed synergistic effects on colon (HCT116), breast (T47D) tumor cells, hepatocellular carcinoma, and periodontal disease. The review also addresses the interaction between these plant extracts with ceramic materials such as hydroxyapatite (HAP) and carotenoids with concrete examples of biomedical applications. Silymarin’s interaction with chemotherapeutic drugs (doxorubicin-DOX, paclitaxel-PCT and 5-Fluorouracil-5-FLU) and gold nanoparticles-GNPs and silver nanoparticles-SNPs is also debated. All these combinations can form composites of major importance in the biomedical field and to contribute significantly to orthopedic surgery where materials are needed for implants that face severe infections. This short review highlights the variety of multifunctional nanoparticles that open new opportunities in cancer treatment and the need to use the Langmuir Blodgett Technique that mimics the biological membrane and provides rich medical information.
Keywords: Silymarin, bioactive compounds, hydroxyapatite, carotenoids, chemotherapeutic drugs, gold nanoparticles, silver nanoparticles
DOI 10.56082/annalsarsciphyschem.2022.2.47
1Babes-Bolyai University, Faculty of Chemistry and Chemical Engineering, Research Centre of Physical Chemistry, 11 Arany Janos Str., RO 400028, Cluj-Napoca, Romania
2 Iuliu Hatieganu University of Medicine and Pharmacy, Department of Orthopedic Surgery, 47 General Traian Mosoiu Str., RO 400132, Cluj-Napoca, Romania
3Academy of Romanian Scientist, 3 Ilfov Str., District 5, RO 050044, Bucharest, Romania
*Corresponding author: Maria Tomoaia-Cotisel, mcotisel@gmail.com
PUBLISHED in Annals of the Academy of Romanian Scientists Series on Physics and Chemistry, Volume 7, No2