Manole COJOCARU1,2
Abstract. Sjögren’s syndrome is a common autoimmune rheumatic disease, identified by its two most common symptoms – dry eyes and a dry mouth. It can also damage other parts of your body, such as joints, thyroid, kidneys, liver, lungs, skin, nerves. Other clinical manifestations are vaginal dryness, non-productive cough, salivary gland swelling and systemic symptoms (arthralgia, fatigue and general discomfort). The unquestionable role of both the innate and adaptive immune system, participating actively in the induction and evolution of the disease, was recognized. This process can manifest either as the independent phenomenon of primary Sjögren’s syndrome or as secondary Sjögren’s syndrome when found in the context of another autoimmune process. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and systemic lupus erythematosus. Sjögren’s syndrome can develop at any age; most people are older than 40 at the time of diagnosis. The condition is much more common in women. The objective of this review paper is to summarize the recent literature on Sjögren’s syndrome, starting from its pathogenesis to systemic manifestations.
Keywords: Sjögren’s syndrome, systemic manifestations.
DOI 10.56082/annalsarscimed.2026.1.9
1 Academy of Romanian Scientists, Bucharest, Romania; e-mail: manole.cojocaru@yahoo.com
2 “Titu Maiorescu” University, Faculty of Medicine, Bucharest, Romania
PUBLISHED in Annals of the Academy of Romanian Scientists Series of Medicine, Volume 7, Issue 1