Ciprian ILIESCU1, Florina Silvia ILIESCU2
Abstract. Liquid biopsy has emerged as a transformative tool in oncology, offering a noninvasive alternative to traditional tissue biopsies. One approach utilizes circulating tumour cells (CTCs) from body fluids such as blood, urine, and saliva to provide insights into tumour genetics and dynamics. A method for isolating CTCs uses the dielectrophoresis phenomenon and microfluidic platforms. The present work reviews the advances in dielectrophoresis on a chip. First, we present the fundamental theory of dielectrophoresis, followed by the main operating principles. We further discuss some of the separation techniques using dielectrophoresis. We finally present the main challenges and concluding remarks. We finally present the main challenges and concluding remarks. Translating DEP technology from lab-scale to industrial applications remains challenging due to the complexities of creating large-scale, non-uniform electric fields Keywords: Dielectrophoresis, Microfluidics, Lab-on-a Chip, Microtechnology, BioMEMS
DOI 10.56082/annalsarsciinfo.2024.2.52
1 Prof., PhD (ABD), Eng., affiliation: eBio-hub Center of Excellence in Bioengineering, National University of Science and Technology POLITEHNICA Bucharest, Bucharest Romania, National Institute for Research and Development in Microtechnologies- IMT Bucharest, Romania, Member of Honour of the Academy of Romanian Scientists, Romania – if the case (ciprian.iliescu@upb.ro).
2PhD, F eBio-hub Center of Excellence in Bioengineering, National University of Science and Technology POLITEHNICA Bucharest, Bucharest Romania, National Institute for Research and Development in Microtechnologies- IMT Bucharest, Romania, (florina.iliescu@upb.ro).
PUBLISHED in Annals of the Academy of Romanian Scientists Series on Science and Technology of Information, Volume 17, No2
ISSN PRINT2066 – 2742 ISSN ONLINE 2066-8562 
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