WHAT IS IBS TODAY AND HOW DO WE TREAT IT? CURRENT GUIDELINES AND POSSIBLE FUTURE NON- PHARMACOLOGICAL TREATMENTS STRATEGIES – A SYSTEMATIC REVIEW

Bogdan RADU-MIHAI1, Alin Stelian CIOBICA2,3,4,5, Ioannis MAVROUDIS6

Abstract: Irritable Bowel Syndrome (IBS) is a prevalent Disorder of Gut-Brain Interaction (DGBI) defined by recurrent abdominal pain and bowel dysfunction. Despite its high prevalence, its complex pathophysiology remains poorly understood, with clinical outcomes often exacerbated by psychological distress and perceived systemic healthcare failures. The absence of diagnostic biomarkers frequently results in exhaustive, inconclusive testing, leading to mutual frustration for patients and clinicians. Given that conventional interventions often yield suboptimal response rates, recent evidence emphasizes the efficacy of integrated biopsychosocial models – specifically those combining structured dietary protocols with psychological support. Furthermore, adjuncts such as curcumin and group therapies show very good results in symptom management. This study evaluates current therapeutic approaches and their limitations and investigates integrative strategies proven to be safe and efficient for patients navigating healthcare systems that lack coordinated, multidisciplinary care.

Keywords: IBS, brain-gut axis, FODMAP, non-pharmacological treatment, psychological interventions

DOI       10.56082/annalsarscibio.2026.1.226

Read full articleDYNAMICS OF THE ΛCDM MODEL OF THE UNIVERSE FROM THE PERSPECTIVE OF THE DYNAMICAL SYSTEMS THEORY                                                                                                                         Download articleDYNAMICS OF THE ΛCDM MODEL OF THE UNIVERSE FROM THE PERSPECTIVE OF THE DYNAMICAL SYSTEMS THEORY

1 Resident, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania (opricandreea15@gmail.com)

2* PhD student, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Romania (delia.luca@student.uaic.ro)

1 Spiru Haret University, Bucharest
2 Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iasi, 700505 Iasi, Romania
3 “Ioan Haulica” Institute, Apollonia University, 700511 Iasi, Romania
4 “Olga Necrasov” Center, Department of Biomedical Research, Romanian Academy, Iasi Branch, 2 Teodor Codrescu Street, 700481 Iasi, Romania
5 Academy of Romanian Scientists, 050094 Bucharest, Romania
6Department of Neurology, Leeds Teaching Hospitals, NHS Trust, Leeds LS2 9JT, UK

PUBLISHED in

Annals Academy of Romanian Scientists Series on Biology,

Volume 15 no 1, 2026

    

ISSN ONLINE85 – 4177
ISSN PRINT 2285 – 4169