| Alina LUPU (ȘURLEA)1*, Ticuţa NEGREANU-PÎRJOL2, Constantin-Andrei RUSALI3, Eugen-Leonard GURGAȘ4, Mihaela BAȘA5, Natalia ROȘOIU6
Abstract: In heart failure and metabolic dysfunction, biomarkers can provide an overview of pathophysiological correlations and mechanisms. The study employed an observational design and was conducted on a sample consisting of two groups: a group of patients with cardiovascular disease, specifically heart failure, with or without comorbidities, and a control group. Biological variables relevant to cardiovascular status and metabolic dysfunction were analyzed, with a focus on the emerging biomarker, Galectin-3. The distribution of biomarker values was evaluated using statistical analyses. The ARCHITECT Galectin-3 immunoassay is a two-step test that utilizes Chemiflex CMIA technology, a technology with flexible testing protocols. When used in conjunction with the ARCHITECT iSYSTEM, it is a test for the quantitative determination of galectin-3 in human serum and EDTA plasma. It is indicated for prognostic assessments in heart failure. In the present study, values of established and emerging cardiovascular biomarkers relevant to cardiovascular status were evaluated and statistically correlated. Other biochemical parameters (lipid profile, blood glucose, liver enzymes, and cardiac markers) relevant to metabolic dysfunction were also included. Galectin-3 is an indicator of cardiac fibrosis and remodeling. The distribution of biomarker values was evaluated using descriptive analysis and coefficients for parametric data and non-Gaussian distributions (Spearman), normality tests (Kolmogorov–Smirnov and Shapiro–Wilk), or tests for comparing biological variables between the two groups. Key correlations of Galectin-3 are relevant for risk stratification in heart failure and reflect the evolving status of the patient’s condition. Established markers such as NT-proBNP/BNP are used in assessing hemodynamic status and correlate with Galectin-3, an indicator of long-term fibrosis. Within the same fibrosis-inflammation axis, it correlates also, with early predictors of cardio-renal syndrome (creatinine/urea) or markers of glycemic status. Keywords: Biomarker, Galectin-3, Cardiac Remodeling, Fibrosis, Methabolic Disorders. DOI 10.56082/annalsarscibio.2026.1.147 Read full article 1 Alina LUPU (ȘURLEA)* – doctorand, IOSUD, Școala Doctorală de Știinte Aplicate, domeniul Biologie, Universitatea „Ovidius” din Constanta, România/ Phd Student, IOSUD, Doctoral School of Applied Science, Biology Domain, „Ovidius” University of Constanța, Romania, E-mail: sl_alina@yahoo.com 2 Prof. univ. dr. Ticuţa NEGREANU-PÎRJOL – Facultatea de Farmacie, Universitatea ”Ovidius” din Constanța, România, Membru asociat al Academiei Oamenilor de Știință din România / Professor, Faculty of Pharmacy,”Ovidius” University of Constanţa, Romania, Associate member of the Academy of Romanian Scientists, Romania, E-mail: ticuta_np@yahoo.com 3 Lect. dr. Constantin-Andrei RUSALI, Facultatea de Medicină, Universitatea ”Ovidius” din Constanța, Romania / Lecturer, Faculty of Medicine, „Ovidius” University of Constanta, Romania, E-mail: andrei1678@yahoo.com 4 Lect. dr. Eugen-Leonard GURGAȘ, Facultatea de Medicină, Universitatea Ovidius din Constanta, Romania / Lecturer, Faculty of Medicine, „Ovidius” University of Constanta, Romania, E-mail: leonard.gurgas@365.univ-ovidius.ro 5 Col. dr. biolog Mihaela BAȘA – Spitalul Militar de Urgență “Alexandru Gafencu” Constanța, Romania /Col. Principal Biologist Phd., Medical Analysis Laboratory ,“Alexandru Gafencu” Military Emergency Hospital of Constanța, Romania, E-mail: mihaela_basa@yahoo.com 6 Prof. univ. emerit dr. CS. I Natalia ROȘOIU – Facultatea de Medicină, Universitatea „Ovidius” din Constanța, România, IOSUD, Școala Doctorală de Științe Aplicate, domeniul Biologie, Universitatea „Ovidius” din Constanța, România, Membru Titular al Academiei Oamenilor de Știință din România și Președinte Secția Științe Biologice / Prof. Emeritus, Faculty of Medicine, „Ovidius” University of Constanța, Romania, Superviser Thesis – IOSUD, Doctoral School of Applied Sciences, Biology Domain, Ovidius University of Constanta, Romania, Full Member of the Academy of the Romanian Scientists and President of the Biological Sciences Section, E-mail: natalia_rosoiu@yahoo.com *Coressponding author E-mail: sl_alina@yahoo.com. |
PUBLISHED in Annals Academy of Romanian Scientists Series on Biology,
ISSN ONLINE85 – 4177
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