| Alina LUPU (ȘURLEA)1*; Ticuţa NEGREANU-PÎRJOL2; Constantin-Andrei RUSALI3, Eugen-Leonard GURGAȘ4 , Mihaela BAȘA5, Natalia ROȘOIU6
Abstract: Heart diseases are among the conditions with high incidence, morbidity, and mortality rates. Research and studies focus both on understanding the pathophysiological mechanisms underlying these conditions and on their interrelationships with associated secondary conditions, such as metabolic disorders. The analysis of biological markers is important for predictability, diagnosis, or staging. Furthermore, numerous studies are focused on potential future therapies based on this research. The aim of present study was an observational, retrospective design and was conducted on a cohort of patients with heart failure. Status was analyzed based on the absence or presence of metabolic comorbidities (diabetes mellitus, dyslipidemia, renal disease). For the correlation analysis, values of cardiovascular, inflammation, and fibrosis biomarkers were used, along with established metabolic markers for renal, hepatic, and glycemic impairment. Distribution of biomarker values was evaluated using descriptive analysis and coefficients for parametric data and non-Gaussian distributions, normality tests, or tests for comparing biological variables in patients with heart failure, systemic cardiovascular disease, and metabolic impairment in cases with associated metabolic dysfunction. The approach to these evaluations must be a multimarker that correlates pathophysiological processes. Assessment of the interdependence of the studied routine analytes has immediate practical value, and the results can be immediately applicable, being easily manageable and financially viable. The need for a multimarker approach also includes new, emerging biomarkers that bring added value and speed to clinical and laboratory evaluation. Kewords: Cardiovascular Markers, Metabolic Disorders, Inflammation, Renal Markers, Liver Markers, Blood Glucose Levels. DOI 10.56082/annalsarscibio.2026.1.140 Read full article 1 Alina LUPU (ȘURLEA)* – doctorand, IOSUD, Școala Doctorală de Știinte Aplicate, domeniul Biologie, Universitatea „Ovidius” din Constanta, România/ Phd Student, IOSUD, Doctoral School of Applied Science, Biology Domain, „Ovidius” University of Constanța, Romania, E-mail: sl_alina@yahoo.com 2 Prof. univ. dr. Ticuţa NEGREANU-PÎRJOL – Facultatea de Farmacie, Universitatea ”Ovidius” din Constanța, România, Membru asociat al Academiei Oamenilor de Știință din România / Professor, Faculty of Pharmacy,”Ovidius” University of Constanţa, Romania, Associate member of the Academy of Romanian Scientists, Romania, E-mail: ticuta_np@yahoo.com 3 Lect. dr. Constantin-Andrei RUSALI, Facultatea de Medicină, Universitatea ”Ovidius” din Constanța, Romania / Lecturer, Faculty of Medicine, „Ovidius” University of Constanta, Romania, E-mail: andrei1678@yahoo.com 4 Lect. dr. Eugen-Leonard GURGAȘ, Facultatea de Medicină, Universitatea Ovidius din Constanta, Romania / Lecturer, Faculty of Medicine, „Ovidius” University of Constanta, Romania, E-mail: leonard.gurgas@365.univ-ovidius.ro 5 Col. dr. biolog Mihaela BAȘA – Spitalul Militar de Urgență “Alexandru Gafencu” Constanța, Romania /Col. Principal Biologist Phd., Medical Analysis Laboratory ,“Alexandru Gafencu” Military Emergency Hospital of Constanța, Romania, E-mail: mihaela_basa@yahoo.com 6 Prof. univ. emerit dr. CS. I Natalia ROȘOIU – Facultatea de Medicină, Universitatea „Ovidius” din Constanța, România, IOSUD, Școala Doctorală de Științe Aplicate, domeniul Biologie, Universitatea „Ovidius” din Constanța, România, Membru Titular al Academiei Oamenilor de Știință din România și Președinte Secția Științe Biologice / Prof. Emeritus, Faculty of Medicine, „Ovidius” University of Constanța, Romania, Superviser Thesis – IOSUD, Doctoral School of Applied Sciences, Biology Domain, Ovidius University of Constanta, Romania, Full Member of the Academy of the Romanian Scientists and President of the Biological Sciences Section, E-mail: natalia_rosoiu@yahoo.com *Coressponding author E-mail: sl_alina@yahoo.com. |
PUBLISHED in Annals Academy of Romanian Scientists Series on Biology,
ISSN ONLINE85 – 4177
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