Dumitru Andrei IACOBAŞ1,2
Abstract. Prostate tumor heterogeneity questions the value of the widely used gene biomarker paradigm for cancer diagnostic and therapy. We quantified the transcriptomic topologies and interplay of the toll-like receptors and chemokine signaling pathways in point biopsies of three cancer nodules and surrounding normal tissue from a surgically removed metastatic prostate. The analysis revealed that the cancer-related topology remodeling is different even between equally graded cancer nodules within the same tumor, pointing to distinct molecular mechanisms of the immune response. Our results invalidate the cancer biomarker paradigm and indicate the necessity to personalize gene anti-cancer therapy beyond individual patient to his/her cancer nodules’ gene master regulators.
Keywords: chemokine signaling, gene master regulators, genomic fabric paradigm, immune response, toll-like receptor signaling.
DOI 10.56082/annalsarscibio.2025.2.130
1 Personalized Genomics Laboratory, Texas Undergraduate Medical Academy, School of Public and Allied Health, Prairie View A&M University, Prairie View, TX77446, U.S.A. Email: daiacobas@pvamu.edu
2Honorary Member, Academy of Romanian Scientists, 3, Ilfov St., 050045 Bucharest, Romania
PUBLISHED in Annals Academy of Romanian Scientists Series on Biological Sciences, Volume 14 no 2, 2025