Ana-Lucia BLENDEA1, Ioana VATA2, Ioan GOTCA3, Andreea GHERASIM4,
Bogdan A. STANA5
Abstract. Sleep disorders are increasingly prevalent in modern society, often resulting from disrupted circadian rhythms and lifestyle-related factors. Circadian rhythms, the body’s internal biological clock, play a critical role in regulating the sleep–wake cycle and overall physiological homeostasis. Phytonutritherapy, which involves the therapeutic use of bioactive compounds from plants with nutritional value, offers a promising complementary approach to managing sleep disturbances. This article explores the interplay between circadian regulation and sleep quality, highlighting the mechanisms through which specific phytonutrients—such as flavonoids, melatonin-like compounds, and essential oils—may influence chronobiological balance. Emphasis is placed on plant-based interventions including valerian root, chamomile, passionflower, and lavender, analyzing current scientific evidence regarding their efficacy and safety. By supporting the realignment of circadian rhythms and enhancing sleep quality, phytonutritherapy may serve as a valuable tool in the integrative management of sleep disorders.
Keywords: circadian rythms, sleep disorders, phytonutritherapy, biological clock, physiological balance
DOI 10.56082/annalsarscibio.2025.1.127
1 Student at Nutrition and Dietetics, UMF Iasi, University of Medicine and Pharmacy
2 Apollonia University, Iasi, Romania
3 Doctor of Medicine, CSM Iasi, Socola Psychiatry Institute
4 Internal Medicine II Department, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T Popa”, 700115 Iasi, Romania
5 MD, PhD, Lecturer in Physiology, “Gr. T. Popa” University of Medicine and Pharmacy, Iași, ROMANIA
PUBLISHED in Annals Academy of Romanian Scientists Series on Biological Sciences, Volume 14 no 1, 2025