| Mihaela Adela Iancu1, Ramona Dorothea Călin1, Adriana Ticărău1, Daniela Popescu1, Ramona Dragomir2, Călin Popovici2, Andrei Kozma2,3,4*, Oana Daniela Toader1,2
Abstract: Endometriosis is a chronic estrogen-dependent inflammatory disorder characterized by the presence of endometrial-like tissue outside the uterine cavity, significantly affecting women’s reproductive health and quality of life. Increasing evidence suggests that dietary factors may play a critical role in modulating inflammatory pathways involved in the pathophysiology and progression of the disease. Nutrition influences immune responses, oxidative stress, estrogen metabolism, and gut microbiota composition, all of which are closely associated with inflammatory activity in endometriosis. This article explores the biological and clinical relationships between dietary patterns and inflammatory mechanisms in endometriosis. Particular attention is given to the impact of pro-inflammatory dietary components, including saturated fats, refined sugars, and ultra-processed foods, which may exacerbate systemic inflammation and hormonal imbalance. Conversely, anti-inflammatory nutrients such as omega-3 fatty acids, antioxidants, polyphenols, fiber, and vitamin D demonstrate potential protective and therapeutic effects through the modulation of cytokine production, oxidative stress, and immune regulation. Clinical evidence supporting nutritional interventions in endometriosis management is also discussed, highlighting the potential benefits of personalized dietary strategies in reducing pain, improving metabolic and hormonal balance, and enhancing overall quality of life. An integrative bio-nutritional approach may represent a valuable complementary strategy in the multidisciplinary management of endometriosis and related inflammatory conditions. Keywords: endometriosis, inflammation, nutrition, oxidative stress, dietary patterns, chronic disease DOI 10.56082/annalsarscibio.2026.1.123 Read full article 1Carol Davila University of Medicine and Pharmacy, Department of Internal, Family and Occupational Medicine, Dionisie Lupu, Bucharest, Romania 2“Alessandrescu-Rusescu” National Institutute for Mother and Child Health Bucharest, Romania 3National Institute of Recovery, Phisycal Medicine and Balneoclimathology, Bucharest, Romania 4Academy of Romanian Scientists, Bucharest, Romania * Correspondingauthor :Sen.res.I-stdgr.Dr.hab.Andrei Kozma (dr.ka.mailox@gmail.com |
PUBLISHED in Annals Academy of Romanian Scientists Series on Biology,
ISSN ONLINE85 – 4177
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