Alexandra AVRAM1, Aurora MOCANU1, Ossi HOROVITZ1, Gheorghe TOMOAIA2,3, Maria TOMOAIA-COTISEL1,3
Abstract. Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAP) is widely used in regards to orthopedic applications due to its similarity to the mineral component in bone. However, while HAP aids with osseointegration it does nothing when it comes to orthopedic infections. Moreover, the prevalence of antibiotic resistance makes treatment even more difficult. In view of this, adding silver to hydroxyapatite has been a focus of many studies due to the combined bioactivity of HAP and excellent antibacterial properties of Ag. The present work brings a brief introduction to more recent studies regarding the HAP-silver combination and its effect on different pathogenic strains. The effect of silver on benign cells is also discussed based on in vitro cultures and in vivo studies.
Keywords: hydroxyapatite, silver ions, silver nanoparticles, antibacterial activity
DOI 10.56082/annalsarsciphyschem.2022.2.7
1 Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Research Centre of Physical Chemistry, 11 Arany Janos Str., RO-400028, Cluj-Napoca, Romania
2 Iuliu Hatieganu University of Medicine and Pharmacy, Department of Orthopedics and Traumatology, 47 General Traian Mosoiu Str., RO-400132, Cluj-Napoca, Romania
3 Academy of Romanian Scientists, 3 Ilfov Str., RO-050044, Bucharest, Romania
*Corresponding author: Maria Tomoaia-Cotisel, mcotisel@gmail.com mocanu.aurora@gmail.com
PUBLISHED in Annals of the Academy of Romanian Scientists Series on Physics and Chemistry, Volume 7, No2