The Role of Astrocytes
in Astrocytes Alzheimer’s Disease
Ioannis MAVROUDIS1,
2 *, Foivos PETRIDIS2, 3,
Symela CHATZIKONSTANTINOU3, Jack McKENN1,
Eleni KARANTALI3, Dimitrios KAZIS3
1 Department of Neurology, Leeds Teaching Hospitals, Leeds, UK
2 Laboratory of Neuropathology and Electron Microscopy, Aristotle
University of Thessaloniki, Greece
3 Third Department of Neurology, Aristotle University of Thessaloniki,
Greece
* Corresponding author e-mail: ioannis.mavroudis@nhs.net
Abstract
Astrocytes are highly specialized glial cells and play a crucial role
in neuronal functionality and brain functional integrity. Although research on
Alzheimer’s disease has been concentrated mainly on the role of neurons,
increasing evidence comes to light marking the important role of astrocytes in
the pathophysiology of Alzheimer’s disease. Astrocytes undergo certain
morphological changes in Alzheimer’s disease and they are thought to
participate in Ab metabolism, and to mediate neurotoxicity and neuronal death
through Calcium signaling.
Here we briefly present the morphological changes of astrocytes and
their role in Alzheimer’s disease neurodegeneration.
Keywords: Astrocytes, Alzheimer’s disease, Ab clearance,
calcium signaling.
DOI https://doi.org/10.56082/annalsarscibio.2020.1.65
