Link
between Imbalanced Gut Microbiome and Systemic Sclerosis
Gheorghe GIURGIU 1 , Manole COJOCARU 2
1Deniplant-Aide Sante Medical Center, Biomedicine,
Bucharest, 012371, Romania 2Titu Maiorescu University, Faculty of Medicine,
Bucharest, 031593, Romania e-mail correspondence author: deniplant@gmail.com
Abstract
Recent research suggests
that the intestinal microbiota influences the development and function of the
immune system, may also play a role in the pathogenesis of autoimmune diseases.
Systemic sclerosis, also known as scleroderma (SD), is a rare disease. Scleroderma
is an immune-mediated systemic autoimmune disease, of unknown etiology, with
high morbidity and mortality. The link between the disease and the imbalance of
the intestinal microbiota suggested that it would contribute to the development
of SD, which is characterized by immune disorder, vasculopathy, organ fibrosis.
Gastrointestinal dysfunction affects 90% of patients with SD and is a leading
cause of morbidity and mortality in these patients. Emerging evidence suggests
that there are changes in the intestinal microbiota in SD, further laboratory
and clinical studies are needed to establish the mechanism by which these
changes perpetuate inflammation and fibrosis in SD. Although several studies
have shown that the intestinal microbiota of patients with SD is abnormal
compared to that of seemingly healthy people, it remains unclear whether
changes in the intestinal microbiota are the result of the disease or the
initial causes. Therapeutic studies are needed to investigate whether dietary
interventions or fecal transplantation can restore intestinal microbial balance
and improve health outcomes. Interventional studies aimed at addressing /
correcting these disorders, either by dietary modification, pro / prebiotic
supplementation or fecal transplantation, may lead to improved outcomes for
patients with SD. It is necessary to further investigate the potential
pathophysiological role of dysbiosis of the intestinal microbiota in triggering
SD, we will discuss natural remedies for modulating the microbiota in SD.
Keywords: : microbiome, dysbiosis,
scleroderma, natural remedies
DOI https://doi.org/10.56082/annalsarscibio.2021.2.61