Immune
Response in Periodontitis and Modulatory Value of Staphylococcal Antigens
Grigore
MIHAESCU1, Paula PERLEA2, Dorin MERCUT3,
Corneliu Ovidiu VRANCIANU1,6, Roxana Elena CRISTIAN4,
Madalina PREDA5, Mariana Carmen CHIFIRIUC 1,6*, Marian
Vladimir CONSTANTINESCU7, Lakshman Perera SAMARANAYAKE8,
Irina CODITA9, Teodor GEORGESCU10
1University of Bucharest, Faculty of Biology,
Microbiology-Immunology Department; ovidiu.vrancianu@yahoo.com; carmen.chifiriuc@bio.unibuc.ro;grigoremihaescu2006@yahoo.com;
roxana.cristian95@yahoo.com
2University of Medicine and Pharmacy "Carol
Davila" Bucharest, Endodontics Department
3 University of Medicine and Pharmacy Craiova
4Department of Biochemistry and Molecular Biology,
Faculty of Biology, University of Bucharest, 020956 Bucharest, Romania
5University of Medicine and Pharmacy Carol Davila;
madalina.prd@gmail.com
6The Research Institute of the University of
Bucharest, Bucharest, Romania;
7Holistic Dental & Medical Institute of Bucharest
ROPOSTURO, Bucharest, Romania
8 University of Sharjah, College of Dental Medicine,
Sharjah, United Arab Emirates
9Cantacuzino National Research and Development
Institute for Microbiology and Immunology, adirina_2005@yahoo.com
10Dr. Georgescu Dental Studio;
georgescuteodor@yahoo.com
Corresponding author: carmen.chifiriuc@bio.unibuc.ro
Abstract
Periodontal disease is a
plaque microbiome related, that disrupts the homeostasis of the periodontium
and the supporting alveolar bone. The aim of this brief review is to offer the
reader the theoretical background of the current status of immunomodulatory
therapies used in the management of periodontitis using staphylococcal
antigens. In response to the hypothesis that Staphylococcus aureus helps
ameliorate periodontal disease, the National Development Institute for
Microbiology and Immunology Cantacuzino, Romania, produced the Staphylococcal
D Vaccine . The proponents of this product claim that Staphylococcal Vaccine is
highly efficacious in the management of periodontitis particularly in patients
with clinical signs of edema, papillary hypertrophy, bleeding on probing, and
pockets > 7 - 8 mm in depth. Although the mechanism of action of
staphylococcal antigen vaccines is elusive as yet, it appears that such
vaccination leads to a dramatic reduction in periodontal inflammation, and
periodontal pocket depth. However, more research is required to obtain
conclusive data on the subject.
Keywords: Staphylococcus; immune response; periodontitis;
inflammation;
modulation
DOI https://doi.org/10.56082/annalsarscibio.2021.2.22