Bioactive
Compounds from Plants Used as Therapeutic Agents in Biomedical Applications – a
Literature Review –
Gertrud-Alexandra PALTINEAN 1 , Sorin RIGA 1,2 , Gheorghe TOMOAIA 2,3 , Aurora MOCANU 1 , Maria TOMOAIA-COTISEL 1,2
1Babes-Bolyai University, Faculty of Chemistry and
Chemical Engineering, Research Centre of Physical Chemistry, 11 Arany Janos
Str., RO 400028, Cluj Napoca, Romania
2Academy of Romanian Scientist, 3 Ilfov, RO 050044,
Bucharest, Romania
3 Iuliu Hatieganu University of Medicine and Pharmacy,
Department of Orthopedic Surgery, 47 General Traian Mosoiu Str., Ro 400132,
Cluj Napoca, Romania
Abstract
This review proposes an
extensive study of some bioactive compounds produced by plants (piperine - PIP,
curcumin - CUC, resveratrol – RES, icariin - ICA) with beneficial effects on
human health. In addition to these compounds, the need for natural pigments,
carotenoids in the body's daily diet and implicitly in nano-science and
medicine is also debated. This study points to complexes of proactive compounds
as well as their interaction with other drugs (e.g., doxorubicin: DOX,
5-fluorouracil: 5-FLU, paclitaxel: PCT) and metal nanoparticles (such as: gold
nanoparticles: GNP, AuNP, and silver nanoparticles: SNP, AgNP) with
applications in cancer cell lines and bacterial investigation, as well as using
viral and fungal strains. This study also opens new opportunities of
multi-functional metallic nanoparticles, realized by self-assemblies through
molecular recognition among bioactive compounds on GNP or SNP, for their
biomedical applications that require continuous development in terms of
infections and the need to treat cancer and other diseases.
Keywords: : plant extract, carotenoids,
flavonoids, plant bioactive compounds, chemotherapeutic drugs, GNP, SNP, health
effect
DOI https://doi.org/10.56082/annalsarscibio.2021.2.103