A
Preliminary Mini-Review on the Relations Between Lipofuscin,
Aging and the Oxidative Stress Status
- the Possible Implications of Gut Functionality
Mahmoud
A. ALI 1*, Alin CIOBICA 2, 3, 4
1 Faculty of Agriculture, Biotechnology Program,
Cairo University, Giza, Egypt
2Department
of Research, Faculty of Biology, Alexandru Ioan Cuza University, B dul Carol I, no 11, Iasi, Romania
3Academy
of Romanian Scientists, Splaiul Independentei
nr. 54, sector 5, 050094 Bucuresti, Romania
4Center
of Biomedical Research, Romanian Academy, Iasi, B dul
Carol I, no 8, Romania
* Corresponding author e-mail: mahmoud.bioinfo@gmail.com.
Abstract
Recently gut microbiome,
genetics, and epigenetics have been incresingly cited
for being involved in aging and longevity. In addition, the oxidative stress
status also has a significant role in the context of aging and longevity, where
also lipofuscin take place and become a hallmark of aging. Thus, in this mini-review we highlighted the
role of the gut microbiome in aging and longevity, and its relationship with antioxidants in the
prevention of age-related diseases. We also discussed the possible mechanistical
aspect for the interactions between lipofuscin, oxidative stress, and aging,
and we reveal additionally a new theory of aging based on the complex
interactions among genetics, microbiome, environment, aging and longevity.
Keywords: Lipofuscin,
Oxidative stress, Aging, Longevity, Microbiome
DOI https://doi.org/10.56082/annalsarscibio.2020.1.43
